Key result
HF patients show a ~3-fold greater decrease in leg vascular resistance during exercise versus controls.
Why the study?
The role of intrinsic skeletal muscle vasodilatory impairment during submaximal exercise in patients with heart failure remains unclear.
Does submaximal bicycle exercise elicit a different muscular blood flow and vascular resistance response in patients with heart failure compared to normal subjects?
Population
30 patients with heart failure and 12 normal subjects
Comparison
Patients with heart failure vs normal control subjects
Design
Observational study using transcutaneous Doppler ultrasonography
Authors
Loading...
Preserved vasodilatory capacity during submaximal exercise in HF; leaves open mechanisms at maximal effort or clinical relevance.
Observational (n=42)
Does submaximal bicycle exercise elicit a different muscular blood flow and vascular resistance response in patients with heart failure compared to normal subjects?
Absolute Event Rate: 5.9% vs 1.9%
p-value: p=< 0.001
The ability of skeletal muscle vascular resistance to decrease is not impaired during submaximal exercise in patients with heart failure, suggesting intrinsic vascular abnormalities do not limit the vasodilator response.
Isnard et al. (1996) conducted an observational in Heart failure (n=42). Heart failure vs. Normal subjects was evaluated on Magnitude of decrease of leg vascular resistance corrected for power (mmHg.l-1.min.W-1) (p=< 0.001). Patients with heart failure demonstrated a greater magnitude of decrease in leg vascular resistance during submaximal exercise compared to normal subjects (5.9 vs 1.9 mmHg.l-1.min.W-1, P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: