Sympathetic vasoconstriction during exercise in ambulatory patients with left ventricular failure.
Key result
Maximal exercise in patients with left ventricular failure significantly increased vascular resistance of nonexercising tissue from 34 to 45 units (p<0.02) without changing total tissue flow.
Authors
Discussion
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Implication
May limit cardiac output augmentation in LV failure; hypothesis-generating for vascular modulation strategies.
Study Design
Type
Observational (n=41)
PICO
P
Population
35 patients with left ventricular failure and 6 normal subjects evaluated for sympathetic vasoconstrictor tone during maximal exercise.
E
Exposure / Comparator
Maximal exercise vs Rest
O
Primary Outcome
Vascular resistance of nonexercising tissue, p=<0.02
Main Result
Absolute Event Rate: 45% vs 34%
p-value: p=<0.02
Cite This Study
Wilson et al. (1989) conducted an observational in left ventricular failure (n=41). Maximal exercise vs. Rest was evaluated on Vascular resistance of nonexercising tissue (p=<0.02). Maximal exercise in patients with left ventricular failure significantly increased vascular resistance of nonexercising tissue from 34 to 45 units (p<0.02) without changing total tissue flow.