Key result
Men and women with HF show similar muscle biochemistry but different adaptations to decreasing peak VO2.
Population
59 subjects: 38 with chronic heart failure (25 men, 13 women) and 21 normal subjects (10 men, 11 women).
Design
Cross-sectional
Authors
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Supports sex-specific HF muscle adaptations; hypothesis-generating and should not yet change practice.
Cross-Sectional (n=59)
Skeletal muscle adaptations to decreasing exercise capacity in chronic heart failure appear to differ between men and women, suggesting gender-specific pathophysiological mechanisms.
Duscha et al. (2001) conducted a cross-sectional in Chronic heart failure (n=59). Female sex vs. Male sex was evaluated on Skeletal muscle biochemistry and histology (oxidative enzymes and capillary density) and relationship to peak VO2. Aerobically matched men and women with chronic heart failure showed no differences in skeletal muscle biochemistry and histology, but adaptations to decreasing peak VO2 differed between sexes.
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