Key result
Chronic heart failure linked to ~18% smaller thigh muscle area and reduced quadriceps strength.
Why the study?
Does chronic heart failure correlate with reduced electromyographic activity and morphological skeletal muscle abnormalities compared to healthy controls?
Population
17 patients with chronic heart failure (LVEF 25+/-2%) and 12 age-matched healthy controls (LVEF 68+/-1%)
Design
Case-control
Authors
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Muscle wasting accompanies chronic heart failure; hypothesis-generating for electromyographic mechanisms and therapeutic targets.
Case-Control (n=29)
Does chronic heart failure correlate with reduced electromyographic activity and morphological skeletal muscle abnormalities compared to healthy controls?
Absolute Event Rate: 134.8% vs 165.2%
p-value: p=0.002
Patients with chronic heart failure exhibit impaired electromyographic activity and muscular function, suggesting a novel pathomechanism contributing to skeletal muscle abnormalities in advanced stages of the disease.
P. et al. (2004) conducted a case-control in Chronic heart failure (n=29). Chronic heart failure vs. Healthy controls was evaluated on Cross-sectional area (CSA) of the thigh (p=0.002). Chronic heart failure was associated with significantly reduced thigh muscle cross-sectional area (134.8 vs 165.2 cm2, P=0.002) and maximal quadriceps strength compared to healthy controls.
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