Key result
Patients with chronic heart failure had higher lactate levels, higher lactate dehydrogenase activity, lower oxidative enzyme activity, and altered muscle fibre composition compared to controls.
Why the study?
Do patients with chronic heart failure have skeletal muscle alterations compared to controls?
Population
43 patients with chronic heart failure and 20 controls
Design
Case-control
Authors
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Skeletal muscle alterations associate with chronic heart failure; hypothesis-generating for their contribution to exercise intolerance and need for prospective studies.
Observational (n=63)
Do patients with chronic heart failure have skeletal muscle alterations compared to controls?
Patients with chronic heart failure exhibit significant skeletal muscle abnormalities, including altered enzyme activity and fiber type shifts, which correlate with exercise capacity and hemodynamics.
Schaufelberger et al. (1997) conducted an observational in chronic heart failure (n=63). Chronic heart failure vs. Controls was evaluated on Skeletal muscle variables (lactate levels, enzyme activity, fibre types, capillarization). Patients with chronic heart failure had higher lactate levels, higher lactate dehydrogenase activity, lower oxidative enzyme activity, and altered muscle fibre composition compared to controls.
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