Chronic heart failure significantly reduced capillary red blood cell velocity during muscle contractions in rats compared to controls (222 vs 428 microm/s, P<0.05).
Does chronic heart failure impair skeletal muscle capillary hemodynamics at rest and during contractions in a rat model?
Chronic heart failure impairs diffusive and conductive O2 delivery across the rest-to-contractions transition in rat skeletal muscle, which may explain the slowed O2 uptake on-kinetics seen in CHF patients.
Absolute Event Rate: 222% vs 428%
p-value: p=<0.05
Chronic heart failure (CHF) reduces muscle blood flow at rest and during exercise and impairs muscle function. Using intravital microscopy techniques, we tested the hypothesis that the speed and amplitude of the capillary red blood cell (RBC) velocity (VRBC) and flux (FRBC) response to contractions would be reduced in CHF compared with control (C) spinotrapezius muscle. The proportion of capillaries supporting continuous RBC flow was less (P 0.05) between CHF and C. Thus CHF impairs diffusive and conductive O2 delivery across the rest-to-contractions transition in rat skeletal muscle, which may help explain the slowed O2 uptake on-kinetics manifested in CHF patients at exercise onset.
Richardson et al. (Mon,) conducted a other in Chronic heart failure. Chronic heart failure (disease model) vs. Healthy control was evaluated on Capillary red blood cell velocity (VRBC) during contractions (p=<0.05). Chronic heart failure significantly reduced capillary red blood cell velocity during muscle contractions in rats compared to controls (222 vs 428 microm/s, P<0.05).