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January 16, 2004Cardiovascular Research

Effects of chronic heart failure on microvascular oxygen exchange dynamics in muscles of contrasting fiber type

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Population

Sprague-Dawley rats with moderate and severe chronic heart failure, and non-infarcted controls

Comparison

Chronic heart failure (moderate and severe) vs Non-infarcted control rats

Design

Preclinical

Authors

BBB BehnkeUniversity of Cologne

Discussion

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Implication

Hypothesis-generating for fiber-specific O2 kinetics in CHF; animal data leave open human translation and clinical relevance.

Structured PICO

P
Population
Sprague-Dawley rats with moderate (n=10) and severe (n=5) chronic heart failure, and non-infarcted controls (n=7)
I
Intervention
Chronic heart failure (moderate and severe)
C
Comparator
Non-infarcted control rats
O
Outcome
Microvascular pO2 mean response time at rest and across the rest-contractions transitionsurrogate

In a rat model, chronic heart failure progressively speeds microvascular O2 pressure dynamics in type I (soleus) but not type II (peroneal) muscle fibers, potentially explaining premature fatigue.

Cite This Study

B Behnke (2004) studied this question.

synapsesocial.com/papers/6a8261bb1fb4be735b3f1646https://doi.org/10.1016/j.cardiores.2003.11.020

Topics

Heart failureHFrEF treatment
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Also Consider

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  1. 1Effects of chronic heart failure on skeletal muscle vascular transport capacity of rats1993 · 31 citations
  2. 2Skeletal muscle metabolism in heart failure in rats1991 · 41 citations
  3. 3Endurance training in rats with chronic heart failure induced by myocardial infarction.1986 · 93 citations
  4. 4Time course of vasodilatory responses in skeletal muscle arterioles: role in hyperemia at onset of exercise2000 · 115 citations
  5. 5Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats1999 · 41 citations