What question did this study set out to answer?

To determine whether congestive heart failure induces contractile or metabolic alterations across different skeletal muscle fiber types.

October 10, 2000Circulation

Heart Failure Affects Mitochondrial but Not Myofibrillar Intrinsic Properties of Skeletal Muscle

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To determine whether congestive heart failure induces contractile or metabolic alterations across different skeletal muscle fiber types.
Evaluated a rat model of congestive heart failure induced by aortic banding, examined 7 months post-surgery.
Assessed permeabilized fibers from slow-twitch soleus and fast-twitch white gastrocnemius muscles for mitochondrial function, mechanical properties, and creatine kinase compartmentation.
Contractile capacity and calcium sensitivity showed no significant change in the soleus muscle despite a slow-to-fast fiber phenotype shift.
Oxidative capacity decreased significantly by 35% in soleus and 45% in white gastrocnemius muscles (P < 0.001) compared to controls.
Mitochondrial creatine kinase activity and content decreased markedly in both muscle types, accompanied by impaired ADP-stimulated respiration regulation in the soleus.

Structured PICO

Population

Rat model of congestive heart failure (CHF) induced by aortic banding

Intervention

Congestive heart failure (disease state)

Comparator

Control rats (implied)

Outcome

Mitochondrial function, mechanical properties, and creatine kinase (CK) compartmentation in situ in permeabilized fibers from soleus and white gastrocnemius musclessurrogate

Congestive heart failure induces a myopathy of metabolic origin in skeletal muscle, characterized by impaired mitochondrial function and phosphotransfer systems but preserved myofibrillar function.

Discussion

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Implication

Supports metabolic skeletal myopathy in experimental CHF; leaves open translation to human disease and therapy.

Cite This Study

Sousa et al. (2000) studied this question.

synapsesocial.com/papers/6a77498bf6b553d308ae64c9 https://doi.org/10.1161/01.cir.102.15.1847

Topics

Heart failure HFrEF treatment

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Heart Failure Affects Mitochondrial but Not Myofibrillar Intrinsic Properties of Skeletal Muscle

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Heart Failure Affects Mitochondrial but Not Myofibrillar Intrinsic Properties of Skeletal Muscle

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider