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August 1, 1999Journal of Applied Physiology

Impaired capillary hemodynamics in skeletal muscle of rats in chronic heart failure

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Population

Rats with chronic heart failure (CHF) 7 weeks after myocardial infarction, and sham-operated controls

Comparison

Chronic heart failure vs Sham-operated controls

Design

Preclinical

Follow-up

7 weeks

Authors

CKCasey A. KindigWalsh UniversityTMTimothy I. MuschHeart Failure & TransplantRBRandall J. BasarabaColorado State University

Discussion

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Implication

May limit skeletal muscle O2 delivery in CHF; hypothesis-generating in rats and requires human validation.

Structured PICO

P
Population
Rats with chronic heart failure (CHF) 7 weeks after myocardial infarction, and sham-operated controls
I
Intervention
Chronic heart failure (induced by myocardial infarction)
C
Comparator
Sham-operated controls
O
Outcome
Red blood cell (RBC) flow distribution, velocity, flux, and capillary density in the spinotrapezius muscle microcirculationsurrogate

In a rat model, chronic heart failure reduces skeletal muscle capillary RBC velocity and flux, which decreases O2 delivery potential but enhances fractional O2 extraction.

Cite This Study

Kindig et al. (1999) studied this question.

synapsesocial.com/papers/6a198d26196cd56b09ea6398https://doi.org/10.1152/jappl.1999.87.2.652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise intolerance in patients with chronic heart failure: role of impaired nutritive flow to skeletal muscle.1984 · 452 citations
  2. 2Capillary length, tortuosity, and spacing in rat myocardium during cardiac cycle1992 · 43 citations
  3. 3Effect of heart failure on muscle capillary geometry: implications for O2 exchange1998 · 34 citations
  4. 4Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure.1989 · 520 citations
  5. 5Changes in skeletal muscle biochemistry and histology relative to fiber type in rats with heart failure1997 · 101 citations