Key result
In open-chest dogs, baroreceptor denervation resulted in autoregulation of total peripheral flow, whereas intact baroreceptor reflexes inhibited this autoregulation to regulate aortic pressure.
Population
Open-chest dogs anesthetized with chloralose-urethane
Comparison
Bilateral vagotomy and carotid sinus denervation… vs Intact baroreceptors with cardiac output varied…
Design
Preclinical
Authors
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No immediate clinical implications; extends foundational understanding of baroreflex-flow interactions in animal models.
Baroreceptor reflexes normally regulate aortic pressure by inhibiting autoregulation in the peripheral circulation.
Liedtke et al. (1973) studied this question. Bilateral vagotomy and carotid sinus denervation vs. Intact baroreceptors was evaluated on Autoregulation of total peripheral flow and aortic pressure regulation. In open-chest dogs, baroreceptor denervation resulted in autoregulation of total peripheral flow, whereas intact baroreceptor reflexes inhibited this autoregulation to regulate aortic pressure.
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