October 1, 1969Circulation ResearchOpen Access

Autoregulation of the Total Systemic Circulation Following Destruction of the Central Nervous System in the Dog

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Population

Dogs with cardiovascular control loops of the central nervous system eliminated by decapitation and alcohol…

Comparison

Changes in arterial pressure vs Baseline/control values prior to arterial…

Design

Preclinical

Follow-up

Up to 75 minutes per step

Authors

HGHarris J. GrangerUniversity of Siena AGArthur C. GuytonEmory University

Discussion

Member takes

Implication

Demonstrates robust local vascular control in canines; leaves open translation to human physiology or clinical relevance.

Structured PICO

Population

Dogs with cardiovascular control loops of the central nervous system eliminated by decapitation and alcohol destruction of the spinal cord

Intervention

Changes in arterial pressure (single-step changes of 25 to 50 mm Hg, or small steps of 10 to 15 mm Hg from 50 to 150 mm Hg)

Comparator

Baseline/control values prior to arterial pressure changes

Outcome

Transient changes and steady-state return of cardiac output, right atrial pressure, oxygen consumption, arteriovenous oxygen difference, and hematocrit; calculated open-loop gain of the autoregulation control systemsurrogate

Total systemic autoregulation provides significant compensation (over 75%) in maintaining capillary pressure and blood flow independent of central nervous system control in a canine model.

Cite This Study

Granger et al. (1969) studied this question.

synapsesocial.com/papers/6a71bdb8ce524a4339c51f35 https://doi.org/10.1161/01.res.25.4.379

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Autoregulation of the Total Systemic Circulation Following Destruction of the Central Nervous System in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Autoregulation of the Total Systemic Circulation Following Destruction of the Central Nervous System in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider