Population
8 dogs under morphine-barbital anesthesia
Design
Preclinical
Authors
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Extends quantitative self-regulation theory in canine models; leaves open translation to human physiology or practice.
In a canine model, systemic and pulmonary circuit pressures showed linear relationships with right heart pump output, supporting a quantitative theory of mechanical self-regulation in the cardiovascular system.
Grodins et al. (1960) studied this question.
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