Key result
Partial exchange transfusion with modified red blood cells decreased cardiac output to 92.5 ml/kg/min and increased total peripheral resistance to 1,144 mmHg/l/kg/min compared to sham transfusion.
Why the study?
Does decreasing hemoglobin oxygen affinity to increase tissue oxygen delivery raise total peripheral resistance in dogs?
Population
12 chronically instrumented dogs
Comparison
Partial exchange transfusion with red blood… vs Exchange transfusion with sham-shifted red blood…
Design
Preclinical
Follow-up
7 days
Authors
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Hypothesis-generating for oxygen delivery in vascular tone regulation; leaves open translation to human hemodynamics.
Does decreasing hemoglobin oxygen affinity to increase tissue oxygen delivery raise total peripheral resistance in dogs?
Increasing tissue oxygen delivery by decreasing hemoglobin oxygen affinity raises total peripheral resistance and decreases cardiac output in dogs, suggesting a role for oxygen delivery in vascular resistance regulation.
Liard et al. (1993) studied this question. Partial exchange transfusion with red blood cells modified by inositol hexaphosphate vs. Exchange transfusion with sham-shifted red blood cells was evaluated on Cardiac output and total peripheral resistance. Partial exchange transfusion with modified red blood cells decreased cardiac output to 92.5 ml/kg/min and increased total peripheral resistance to 1,144 mmHg/l/kg/min compared to sham transfusion.
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