Why the study?
Does acute transfusion of sedimented red cells alter coronary blood flow and myocardial oxygen consumption in patients with blood-loss anemia and normovolemic dogs?
Population
Patients with substantial blood-loss anemia and normovolemic dogs
Comparison
Acute transfusion of sedimented red cells vs Baseline (pre-transfusion)
Design
Other
Follow-up
Acute
Authors
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May warrant caution with rapid hematocrit rises in anemic patients; leaves open effects on ischemia risk and optimal transfusion strategies.
Does acute transfusion of sedimented red cells alter coronary blood flow and myocardial oxygen consumption in patients with blood-loss anemia and normovolemic dogs?
Acute red cell transfusion reduces coronary blood flow, a finding that appears to be related principally to enhanced blood viscosity rather than ischemia or hemodynamic changes.
Regan et al. (1963) studied this question.
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