September 1, 1980AJP Heart and Circulatory Physiology
Coronary hemodynamics and oxygen utilization after hematocrit variations in hemorrhage
Population
20 closed-chest dogs anesthetized with pentobarbital sodium undergoing hemorrhagic hypotension
Comparison
Variations of hematocrit achieved by exchange of… vs Different levels of hematocrit
Design
Preclinical
Authors
Discussion
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Implication
Highlights potential mismatch in hematocrit optimization between coronary and systemic beds during hemorrhage; leaves open relevance to human transfusion practice.
Structured PICO
P
Population
20 closed-chest dogs anesthetized with pentobarbital sodium undergoing hemorrhagic hypotension (mean arterial pressure maintained at 50 mmHg)
I
Intervention
Variations of hematocrit (Hct) achieved by exchange of blood with plasma or packed cells
C
Comparator
Different levels of hematocrit
O
Outcome
Coronary hemodynamics (coronary blood flow, cardiac output, vascular resistance) and myocardial oxygen utilizationsurrogate
In a canine model of hemorrhagic hypotension, the optimal hematocrit for maximum oxygen transport differs significantly between coronary (25%) and systemic (45%) circulations.
Cite This Study
Jan et al. (1980) studied this question.