Key result
Hemodilution with low molecular weight dextran increased collateral blood flow to ischemic muscle areas by up to 50%, whereas high molecular weight dextran raised blood viscosity and reduced flow.
Why the study?
Do variations in hematocrit and blood viscosity affect normal and collateral myocardial blood flow during temporary coronary occlusions in dogs?
Do variations in hematocrit and blood viscosity affect normal and collateral myocardial blood flow during temporary coronary occlusions in dogs?
In a canine model, hemodilution with low molecular weight dextran improves collateral blood flow during coronary occlusion, while increasing blood viscosity with high molecular weight dextran impairs it.
No takes yet. Share an insight, caveat, or question.
Does not support clinical use of dextran hemodilution; leaves open viscosity effects on human collateral myocardial flow.
Johansson et al. (1967) studied Temporary coronary occlusions. Variations in hematocrit and blood viscosity (LMD and HMD) vs. Baseline (before variations) was evaluated on Normal and collateral coronary blood flow. Hemodilution with low molecular weight dextran increased collateral blood flow to ischemic muscle areas by up to 50%, whereas high molecular weight dextran raised blood viscosity and reduced flow.
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