Why the study?
Does progressive isovolemic hemodilution and halothane anesthesia affect regional LV contractile function in dogs with compromised coronary blood flow?
Does progressive isovolemic hemodilution and halothane anesthesia affect regional LV contractile function in dogs with compromised coronary blood flow?
Severe hemodilution to a hematocrit of ~15% causes significant regional left ventricular dysfunction in the setting of critical coronary stenosis, independent of halothane anesthesia levels.
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Extreme hemodilution to ~15% hematocrit may impair regional LV function in critical coronary stenosis independent of halothane; hypothesis-generating for human transfusion thresholds.
Spahn et al. (1992) studied this question.
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