Why the study?
Does increasing halothane concentration cause regional ischemic ventricular dysfunction in myocardium supplied by a narrowed coronary artery in dogs?
Population
11 open-chested dogs with a critically narrowed left anterior descending coronary artery and a normal left…
Comparison
Increasing inspired halothane concentration… vs Baseline and normal coronary artery territory
Design
Preclinical
Authors
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Halothane may provoke regional ischemia in stenotic canine territories; leaves open relevance to modern anesthetics or human CAD.
Does increasing halothane concentration cause regional ischemic ventricular dysfunction in myocardium supplied by a narrowed coronary artery in dogs?
Increasing halothane concentrations in the presence of a critically narrowed coronary artery can induce regional myocardial ischemia due to decreased perfusion pressure.
Lowenstein et al. (1981) studied this question.
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