Why the study?
Does halothane anesthesia reduce myocardial infarct size and alter hemodynamics in dogs following coronary artery occlusion?
Population
28 anesthetized mongrel dogs subjected to left anterior descending coronary artery (LAD) ligation.
Comparison
Halothane inhalation. vs No further intervention.
Design
Preclinical, Randomly assigned
Follow-up
24 hours
Authors
Loading...
Hypothesis-generating in canine models; human trials needed before any clinical consideration.
Does halothane anesthesia reduce myocardial infarct size and alter hemodynamics in dogs following coronary artery occlusion?
Halothane anesthesia is associated with a significant reduction in myocardial infarct size and reduced left ventricular contractile and pump performance in a canine model of coronary occlusion.
Davis et al. (1983) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: