Halothane and the Reperfusion Injury in the Intact Animal Model

View Full Paper

Ask AI

Bookmark

Why the study?

Does halothane improve regional myocardial function and reduce arrhythmias during acute ischemia and reperfusion in a pig model?

Structured PICO

Does halothane improve regional myocardial function and reduce arrhythmias during acute ischemia and reperfusion in a pig model?

Population

32 open-chest pigs subjected to 15 min of total left anterior descending coronary artery (LAD) occlusion followed by 120 min of reperfusion

Intervention

Halothane (0.2%, 0.4%, 0.6%, or 0.8%) added to pentobarbital and fentanyl anesthesia

Comparator

Pentobarbital and fentanyl anesthesia alone

Outcome

Regional myocardial function (systolic and diastolic) and incidence of ventricular arrhythmias during acute ischemia and reperfusionsurrogate

In a pig model of ischemia-reperfusion, halothane administration improved recovery of regional systolic function and reduced reperfusion arrhythmias.

No takes yet. Share an insight, caveat, or question.

Does not support clinical use; leaves open whether halothane confers cardioprotection in human ischemia-reperfusion.

Coetzee et al. (1993) studied this question.

View Full Paper

Ask AI

Bookmark