Key result
Hemorrhagic hypotension in dogs reduces oxygen consumption ~50% at 10 minutes before partially rebounding.
Population
220 dogs subjected to hemorrhagic hypotension with arterial pressure lowered to and maintained at 30 mm Hg
Comparison
Pretreatment with Dibenzyline, epinephrine… vs Control state prior to hemorrhage and untreated…
Design
Preclinical
Follow-up
1 hour
Authors
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Hypotension-induced oxygen consumption changes in dogs should not guide human care; leaves open translational relevance to clinical hemorrhagic shock.
Absolute Event Rate: 3.58% vs 7.2%
In a canine model of hemorrhagic hypotension, oxygen consumption initially drops but partially recovers over 1 hour, with Dibenzyline increasing early oxygen consumption and epinephrine decreasing it.
Smith et al. (1964) studied Hemorrhagic hypotension (n=220). Hemorrhagic hypotension vs. Pre-hemorrhage baseline was evaluated on Oxygen consumption. Hemorrhagic hypotension to 30 mm Hg in dogs decreased average oxygen consumption from 7.20 ml/kg min to 3.58 ml/kg min at 10 minutes, followed by a rise to 5.33 ml/kg min after 1 hour.
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