Population
Anesthetized dogs subjected to hemorrhagic hypotension (blood pressure maintained at 50 mm Hg for 3 hours)
Comparison
Reinfusion of blood, low molecular weight… vs Control conditions (baseline before hemorrhage)
Design
Preclinical
Authors
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May support low-MW dextran in experimental shock; hypothesis-generating and should not change human practice.
In a canine model of hemorrhagic hypotension, low molecular weight dextran was superior to whole blood or high molecular weight dextran in restoring normal intrarenal blood flow distribution.
Carrière et al. (1970) studied this question.
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