What question did this study set out to answer?

To determine how acute hemorrhage and subsequent retransfusion affect the distribution of blood flow between the renal cortex and medulla.

March 1, 1968Journal of Clinical InvestigationOpen Access

Effect of hemorrhage and retransfusion on intrarenal distribution of blood flow in dogs

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Why the study?

Does hemorrhagic hypotension and subsequent retransfusion alter the intrarenal distribution of blood flow in dogs?

Population

12 dogs anesthetized with Nembutal

Comparison

Bleeding to a mean arterial pressure of 50-65 mm… vs Baseline/control values prior to bleeding

Design

Preclinical

Follow-up

2-3 hours of hypotension plus reinfusion period

Authors

KAKnut AuklandUppsala University MWM. WolgastUppsala University

Discussion

Member takes

Implication

May support uniform renal vasoconstriction in canine hemorrhage; hypothesis-generating for human hypovolemic AKI mechanisms.

Key Points

To determine how acute hemorrhage and subsequent retransfusion affect the distribution of blood flow between the renal cortex and medulla.
Studied 12 Nembutal-anesthetized dogs subjected to acute bleeding to maintain a mean arterial pressure of 50-65 mm Hg for 2-3 hours followed by blood reinfusion.
Measured outer medullary blood flow using polarographic hydrogen gas clearance, 85Kr clearance, and 32P-labeled erythrocyte transit times.
Estimated cortical and total renal blood flow using cortical red cell transit times and electromagnetic flowmetry.
Hemorrhagic hypotension reduced cortical and medullary blood flow to the same extent, with sustained hypotension causing progressive flow reductions out of proportion to the decrease in arterial pressure.
Blood reinfusion after 2-3 hours of hypotension restored total renal blood flow to an average of 82% and outer medullary hydrogen clearance to an average of 92% of control values.
All animals survived without evidence of renal failure, showing no selective hemodynamic diversion in the juxtamedullary circulation.

Structured PICO

Does hemorrhagic hypotension and subsequent retransfusion alter the intrarenal distribution of blood flow in dogs?

Population

12 dogs anesthetized with Nembutal

Intervention

Bleeding to a mean arterial pressure of 50-65 mm Hg for 2-3 hours followed by reinfusion of blood

Comparator

Baseline/control values prior to bleeding

Outcome

Intrarenal distribution of blood flow (cortical and medullary blood flow)surrogate

Hemorrhagic hypotension in dogs leads to a progressive and uniform rise in renal vascular resistance without selective hemodynamic response in the juxtamedullary circulation.

Cite This Study

Aukland et al. (1968) studied this question.

synapsesocial.com/papers/6a76b80a9d809400dabd446f https://doi.org/10.1172/jci105745

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Effect of hemorrhage and retransfusion on intrarenal distribution of blood flow in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of hemorrhage and retransfusion on intrarenal distribution of blood flow in dogs

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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