August 1, 1971European Journal of Clinical Investigation

Pathogenesis of Redistribution of Intrarenal Blood Flow in Haemorrhagic Hypotension* **

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Population

19 anaesthetised dogs with haemorrhagic hypotension

Comparison

Infusion of acetylcholine, papaverine, or… vs Normal blood pressure and haemorrhagic…

Design

Preclinical

Authors

AGA GrandchampMontreal Heart Institute GAG. AyerLuzerner Kantonsspital BTB. TrunnigerUniversity Hospital of Bern

Discussion

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Implication

Alpha-adrenergic blockade preserves renal perfusion in animal haemorrhagic shock; leaves open translation to human patients.

Structured PICO

Population

19 anaesthetised dogs with haemorrhagic hypotension

Intervention

Infusion of acetylcholine, papaverine, or alpha-adrenergic blockade (phenoxybenzamine or phentolamine) into the renal artery

Comparator

Normal blood pressure and haemorrhagic hypotension before infusion

Outcome

Intrarenal distribution of blood flow (IDBF) and local blood flow rates (F1) measured by 133 Xenon washout technique and 85 Krypton autoradiographiessurrogate

Sympathoadrenergic factors are primarily responsible for the redistribution of renal blood flow during haemorrhagic hypotension.

Cite This Study

Grandchamp et al. (1971) studied this question.

synapsesocial.com/papers/6a871bb9385344fed8cb8f2f https://doi.org/10.1111/eci.1971.1.4.271

View Full Paper

Ask AI

Bookmark

Pathogenesis of Redistribution of Intrarenal Blood Flow in Haemorrhagic Hypotension* **

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathogenesis of Redistribution of Intrarenal Blood Flow in Haemorrhagic Hypotension* **

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider