Population
Anesthetized dogs subjected to a uniform 15-17% reduction in blood pressure by hemorrhage
Comparison
Beta adrenergic blockade, renal prostaglandin… vs Control dogs undergoing hemorrhage without…
Design
Preclinical
Authors
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Renin release during hemorrhage requires multi-pathway blockade in this model; leaves open translation to human shock management.
Renin release during hemorrhage is multifactorial, involving beta adrenergic receptors, renal baroreceptors, and possibly the macula densa, with the latter two likely being prostaglandin-mediated.
Henrich et al. (1979) studied this question.
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