Why the study?
Does prostaglandin synthesis inhibition and renal denervation alter renal hemodynamics and plasma renin activity during hypotensive hemorrhage in dogs?
Population
24 dogs subjected to hypotensive hemorrhage (30% decrement in arterial blood pressure)
Comparison
Prostaglandin synthesis inhibition with RO… vs Control group without prostaglandin inhibition…
Design
Preclinical
Authors
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Suggests prostaglandins protect renal hemodynamics in canine hemorrhage; hypothesis-generating but leaves open human translation.
Does prostaglandin synthesis inhibition and renal denervation alter renal hemodynamics and plasma renin activity during hypotensive hemorrhage in dogs?
Renal prostaglandins attenuate the decrease in GFR and RBF during hypotensive hemorrhage, and renal denervation protects against the enhanced ischemic effects of prostaglandin inhibition.
Henrich et al. (1978) studied this question.
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