Why the study?
How do circulating vasoactive substances change during hemorrhagic shock in dogs, and what is the hemodynamic effect of their pharmacologic manipulation?
Population
Dogs subjected to hemorrhagic shock (bled to 45-50 mm Hg)
Design
Preclinical
Authors
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Animal data on compensatory mediators in hemorrhage leave open therapeutic targeting; should not change practice.
How do circulating vasoactive substances change during hemorrhagic shock in dogs, and what is the hemodynamic effect of their pharmacologic manipulation?
The renin-angiotensin system and catecholamines play distinct roles in maintaining vascular resistance during hemorrhagic shock, suggesting that targeted antagonist therapy could potentially improve organ perfusion.
Jakschik et al. (1974) studied this question.
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