Why the study?
Does 1-sarcosine-8-alanine-angiotensin II reduce mean arterial pressure in conscious dogs following hemorrhage?
Population
Conscious dogs subjected to hemorrhage (20 ml/kg body wt)
Comparison
1-sarcosine-8-alanine-angiotensin II infused… vs Pre-infusion posthemorrhage state
Design
Preclinical
Follow-up
90 minutes (30 min infusion, 60 min recovery)
Authors
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Ang II analog lowers post-hemorrhage MAP in dogs; confirms compensatory role but leaves human translation open.
Does 1-sarcosine-8-alanine-angiotensin II reduce mean arterial pressure in conscious dogs following hemorrhage?
Endogenous angiotensin II plays an important role in the short-term compensatory maintenance of arterial pressure following hemorrhage.
Freeman et al. (1975) studied this question.
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