August 1, 1999Journal of Hypertension

Haemorrhage increases the pressor effect of angiotensin-(1–7) but not of angiotensin II at the rat rostral ventrolateral medulla

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Structured PICO

Population

79 urethane-anaesthetized male Wistar rats submitted to haemorrhage (blood withdrawal of 0.6 ml/100 g bodyweight)

Intervention

Bilateral micro-injections of Ang-(1-7) (2.5 and 25 pmol), Ang II (25 pmol), [Sar1,Thr8]-Ang II (0.2 nmol), A-779 (0.1 nmol), or losartan (0.2 nmol) into the rostral ventrolateral medulla (RVLM) under basal conditions, 30 min after blood withdrawal, or 10 min before bleeding

Comparator

Vehicle (200 nl) micro-injection

Outcome

Changes in mean arterial pressure (MAP) and heart rate (HR)surrogate

In a rat model of haemorrhage, RVLM reactivity to Ang-(1-7) is increased, suggesting its contribution to haemodynamic adjustments during acute blood volume reduction.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Does not support clinical translation; leaves open Ang-(1-7) contribution to RVLM compensation in human hemorrhage.

Cite This Study

Lima et al. (1999) studied this question.

synapsesocial.com/papers/6a90882af5c79ce9992dbcbe https://doi.org/10.1097/00004872-199917080-00014

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Haemorrhage increases the pressor effect of angiotensin-(1–7) but not of angiotensin II at the rat rostral ventrolateral medulla

Structured PICO

Discussion

Implication

Cite This Study

Haemorrhage increases the pressor effect of angiotensin-(1–7) but not of angiotensin II at the rat rostral ventrolateral medulla

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider