Key result
Intracerebroventricular losartan and saralasin markedly lower blood pressure and reduce tachycardia during hemorrhage in rats.
Why the study?
The physiological role of brain angiotensin II acting through AT1 receptors in mediating cardiovascular, vasopressin, and renin responses to hemorrhage was unclear across different rat strains.
Population
Conscious spontaneously hypertensive rats and normotensive Wistar-Kyoto and Wistar rats
Comparison
Intracerebroventricular losartan and saralasin vs artificial cerebrospinal fluid control
Design
Preclinical experimental study
Authors
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Central AT1 blockade modulates rat hemorrhage responses; hypothesis-generating for vasopressin regulation, leaves open human translation.
Brain ANG II acting through AT1 receptors plays an important physiological role in mediating rapid cardiovascular regulation and vasopressin release in response to hemorrhage in specific rat strains.
Lee et al. (1995) studied Hemorrhage. Intracerebroventricular losartan and saralasin vs. artificial cerebrospinal fluid control was evaluated on blood pressure and tachycardia during and after hemorrhage. Intracerebroventricular administration of losartan and saralasin produced a markedly greater fall in blood pressure and reduced tachycardia during and after hemorrhage in SHR and Wistar rats.
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