Key result
Dextran 70 hemodilution to ~28% hematocrit increases myocardial blood flow and cardiac output.
Why the study?
The effects of hemodilution on myocardial blood flow, oxygen consumption, and carbon dioxide release in humans were not fully characterized.
Does hemodilution with Dextran 70 affect myocardial blood flow, oxygen uptake, and carbon dioxide release in humans?
Population
Humans undergoing hemodilution
Comparison
Before and during hemodilution with Dextran 70 reducing hematocrit from 37 to 28%
Design
Physiological study measuring myocardial blood flow and metabolism
Authors
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Supports myocardial oxygenation during moderate hemodilution; leaves open applicability to current practice pending higher-level confirmation.
Does hemodilution with Dextran 70 affect myocardial blood flow, oxygen uptake, and carbon dioxide release in humans?
Blood losses up to 20% of total blood volume can be replaced by dextran solutions without a significant decrease in myocardial oxygen supply, as compensatory increases in cardiac output and myocardial blood flow maintain oxygenation.
Gisselsson et al. (1982) studied this question. Hemodilution with Dextran 70 vs. Baseline (before hemodilution) was evaluated on Myocardial blood flow, oxygen consumption and carbon dioxide release. Hemodilution with Dextran 70 (reducing hematocrit from 37% to 28%) increased myocardial blood flow and cardiac output, maintaining unchanged coronary sinus oxygen tension and respiratory quotient.
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