What question did this study set out to answer?

The study aims to understand the mechanism behind arterial hypoxemia following pulmonary thromboembolism in dogs.

Mechanism of arterial hypoxemia following pulmonary thromboembolism in dogs

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Randomized trial investigates arterial hypoxemia in dogs post-thromboembolism, indicating lung mechanics changes.

The study aims to understand the mechanism behind arterial hypoxemia following pulmonary thromboembolism in dogs.
29 mongrel dogs were used, anesthetized, paralyzed, and ventilated at a constant minute volume.
Measurements included AaD02, Qva/Qt, Qs/Qt, DLCO, RL, and CL before and after pulmonary embolization with thrombi.
Nine dogs were heparinized prior to embolization while twenty were not.
In nonheparinized dogs, AaDo2 increased from 11 to 26 mmHg, Qva/Qt from 4% to 22%, Qs/Qt from 5% to 8%; DLCO decreased by 24%.
In heparinized dogs, AaDo2 increased from 8 to 13 mmHg, Qva/Qt from 3% to 8%; Qs/Qt remained unchanged, DLCO decreased by 31%.
Heparinized dogs exhibited a significantly smaller increase in Qva/Qt (5%, P<0.001) compared to nonheparinized dogs (18%).

Levy et al. (1975) studied this question.

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