January 1, 1956Circulation ResearchOpen Access

Effects of Pulmonary Embolism on the Pulmonary Circulation With Special Reference to Arteriovenous Shunts in the Lung

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Population

anesthetized dogs

Design

Preclinical

Authors

ANAlbert H. NidenUniversity of Southern California DADomingo M. AviadoSemmelweis University

Discussion

Member takes

Implication

Animal PE data delineate reflex pathways; leaves open human translation and therapeutic implications.

Structured PICO

Population

anesthetized dogs

Intervention

Pulmonary embolism induced by injection of glass beads

Outcome

Physiological responses including bradycardia, apnea, respiratory stimulation, and pulmonary hypertensionsurrogate

This preclinical study demonstrates that the physiological responses to pulmonary embolism, including bradycardia, apnea, and hypertension, are mediated by complex reflex mechanisms involving the vagus nerve, sympathetics, and chemoreceptors.

Cite This Study

Niden et al. (1956) studied this question.

synapsesocial.com/papers/6a828e775b7acbbacb8d5a9d https://doi.org/10.1161/01.res.4.1.67

Topics

Pulmonary embolism

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Effects of Pulmonary Embolism on the Pulmonary Circulation With Special Reference to Arteriovenous Shunts in the Lung

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Effects of Pulmonary Embolism on the Pulmonary Circulation With Special Reference to Arteriovenous Shunts in the Lung

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider