Why the study?
Does pretreatment with proteinase inhibitor prevent pulmonary hypertension caused by vasoactive substances in a dog model of pulmonary embolism?
Population
Dog model with pulmonary artery balloon obstruction
Design
Preclinical
Authors
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May partially attenuate humoral PH in experimental PE; leaves open clinical translation of proteinase inhibitors.
Does pretreatment with proteinase inhibitor prevent pulmonary hypertension caused by vasoactive substances in a dog model of pulmonary embolism?
Stasis of vasoactive substances may contribute to the humoral component of pulmonary hypertension in pulmonary embolism, which can be partially blocked by proteinase inhibitors.
William M. Hamilton (1972) studied this question.
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