Key result
Clinical-dose heparin protects ~94% of dogs exposed to serotonin and small blood clots.
Why the study?
Does heparin protect against the physiological effects of serotonin and experimental pulmonary embolism in dogs?
Population
Dogs (experimental model of pulmonary embolism)
Design
Preclinical
Authors
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Heparin protection in canine embolism model warrants caution in humans; leaves open translation to clinical pulmonary embolism.
Does heparin protect against the physiological effects of serotonin and experimental pulmonary embolism in dogs?
Heparin exerts a protective effect against the physiological consequences of experimental pulmonary embolism and serotonin infusion in dogs, supporting its emergency use in pulmonary embolism.
Cobb et al. (1960) studied Experimental Pulmonary Embolism. Heparin was evaluated on Protective effect to infusion of serotonin and multiple small fresh blood clots. Heparin in clinical doses exerted a protective effect in 94% of dogs exposed to serotonin infusion and multiple small fresh blood clots.
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