What question did this study set out to answer?

To evaluate how sudden increases in blood flow alter pulmonary vascular resistance in lungs affected by serotonin-induced or embolic pulmonary hypertension.

September 1, 1963American Journal of Physiology-Legacy Content

Behavior of pulmonary hypertension produced by serotonin and emboli

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Authors

JHJohn W. HylandBaylor University Medical Center TPThomas E. PiemmeWested SASidney AlexanderLahey Medical Center

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Implication

Experimental study demonstrates active precapillary vasodilatation during increased flow in canine pulmonary hypertension, suggesting active arteriole resistance regulation.

Key Points

To evaluate how sudden increases in blood flow alter pulmonary vascular resistance in lungs affected by serotonin-induced or embolic pulmonary hypertension.
Induced pulmonary hypertension in 25 dogs using infusions of serotonin, lycopodium spores, or polystyrene spheres.
Doubled blood flow through one lung via balloon occlusion of the contralateral pulmonary artery and measured changes in calculated pulmonary vascular resistance.
Balloon occlusion produced a 51% reduction in pulmonary vascular resistance in the unoccluded lung with serotonin-induced hypertension and a 47% reduction with small 28 µm precapillary emboli.
Hypertension caused by larger polystyrene spheres produced only an 18% fall in resistance without significant vasodilatation, indicating precapillary arterioles actively regulate resistance.

Cite This Study

Hyland et al. (1963) studied this question.

synapsesocial.com/papers/6a71602da7fbea1e44086552 https://doi.org/10.1152/ajplegacy.1963.205.3.591

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Implication

Experimental study demonstrates active precapillary vasodilatation during increased flow in canine pulmonary hypertension, suggesting active arteriole resistance regulation.

Behavior of pulmonary hypertension produced by serotonin and emboli

Discussion

Member takes

Implication

Key Points

Cite This Study

Behavior of pulmonary hypertension produced by serotonin and emboli

Discussion

Member takes

Implication

Key Points

Cite This Study

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