Active serotonin appears to be released from circulating blood platelets and plays a role in pulmonary circulatory disturbances such as pulmonary hypertension and embolism.
May implicate platelet serotonin in pulmonary hypertension; hypothesis-generating and requires human validation.
The estimation of whole blood serotonin and the related substances and analysis of the haemodynamic effects in serotonin administration were made in man and dog. In cardiac patients with pulmonary hypertension, notwithstanding their elevated reactivity of pulmonary circulation to serotonin, whole blood serotonin levels were markedly lowered. Prominent decrease of whole blood serotonin and blood platelet, increase of urinary excretion of 5-hydroxyindole acetic acid and the rise of the pulmonary arterial pressure were noted in the experimental pulmonary embolism with auto-clot in dogs. Active serotonin seemed to be released from the circulating blood platelet to play some roles in the pulmonary circulatory disturbances.
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K Yoshitake (1967) studied this question.
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