Why the study?
Does serotonin infusion alter systemic and coronary hemodynamics in anesthetized dogs?
Population
Dogs anesthetized with morphine and Dial-urethane-Nembutal
Comparison
Mechanical infusion of 20 µg/kg/min of serotonin… vs Baseline measurements (before infusion)
Design
Preclinical
Follow-up
25 minutes
Authors
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Does not inform human practice; leaves open serotonin's coronary effects for mechanistic studies.
Does serotonin infusion alter systemic and coronary hemodynamics in anesthetized dogs?
Serotonin acts as a powerful coronary vasodilator, increasing myocardial oxygen supply without increasing left ventricular work in a canine model.
Maxwell et al. (1959) studied this question.