Key result
Continuous infusion of 5-hydroxytryptamine at 150 µg/kg/min in dogs increased mean pulmonary pressure by 300% and pulmonary resistance by 500%, while decreasing systemic resistance by 55%.
Why the study?
Does continuous infusion of 5-hydroxytryptamine alter pulmonary and systemic hemodynamics in dogs?
Population
8 dogs with chronic catheterization of the pulmonary artery, aorta, and in some animals, the left auricle
Comparison
Continuous venous infusion of… vs Baseline (control levels prior to infusion)
Design
Preclinical
Authors
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Highlights serotonin's pulmonary vasoconstrictor effects in dogs; leaves open its role in congenital heart disease-associated pulmonary hypertension.
Does continuous infusion of 5-hydroxytryptamine alter pulmonary and systemic hemodynamics in dogs?
Continuous infusion of serotonin in dogs acts as a powerful pulmonary vasoconstrictor and peripheral vasodilator, suggesting a potential role in the development of pulmonary hypertension in congenital heart disease.
Rudolph et al. (1957) studied this question. 5-Hydroxytryptamine (Serotonin) vs. Baseline/control levels was evaluated on Pulmonary and systemic vascular responses (pulmonary arterial pressure, systemic arterial pressure, cardiac output, and resistances). Continuous infusion of 5-hydroxytryptamine at 150 µg/kg/min in dogs increased mean pulmonary pressure by 300% and pulmonary resistance by 500%, while decreasing systemic resistance by 55%.