Why the study?
Does 5-hydroxytryptamine alter pulmonary hemodynamics in dog models?
Does 5-hydroxytryptamine alter pulmonary hemodynamics in dog models?
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The study demonstrates that 5-HT induces pulmonary vasoconstriction and suggests the resulting increase in pulmonary blood flow in intact dogs is partly a sympathetic reflex.
The pulmonary hypertensive response to 5-HT in the dog heart-lung preparation is largely due to pulmonary vasoconstriction. There is an unexpected fall in aortic blood flow but no rise in left atrial pressure. In intact dogs the pulmonary hypertensive response is accompanied by an increase in pulmonary blood flow which is in turn partly reduced by upper thoracic sympathectomy. It is suggested that the rise in pulmonary blood flow is partly a sympathetic reflex initiated by pulmonary vasoconstriction by 5-HT.
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Duteil et al. (1962) studied this question.
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