Key result
Continuous intravenous infusion of serotonin lowered pulmonary blood volume by an average of 2.9 ml/kg, or 26% of the control value.
Why the study?
Does continuous intravenous infusion of serotonin alter pulmonary blood volume in dogs?
Does continuous intravenous infusion of serotonin alter pulmonary blood volume in dogs?
Serotonin significantly decreases pulmonary blood volume in dogs, indicating constriction of the pulmonary vascular bed and a shift of blood to systemic circuits.
Answers are grounded in this paper and cite their sources.
Serotonin reduces pulmonary blood volume in dogs; leaves open translation to human pulmonary vascular physiology or therapy.
Changes in pulmonary blood volume produced by continuous intravenous infusion of serotonin (5-hydroxytryptamine) were measured in 16 experiments on ten dogs. Pulmonary mean transit time was measured by the dye dilution method, using consecutive injections into pulmonary artery and left atrium; pulmonary blood volume was calculated by multiplying this mean transit time by the cardiac output. Serotonin lowered pulmonary blood volume by an average of 2.9 ml/kg, or 26% of the control value ( P <0.001). Pulmonary vascular resistance increased 94 ru (resistance units) kg, and systemic vascular resistance fell 294 ru kg, effects similar to those reported by other investigators. The magnitude of the decrease in pulmonary blood volume indicates that a relatively large part of the pulmonary vascular bed is constricted by serotonin, and provides an example of shifting of blood from pulmonic to systemic circuits by reciprocal changes in the distensibility of these beds.
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McGaff et al. (1962) studied this question. Continuous intravenous infusion of serotonin (5-hydroxytryptamine) vs. Control value (baseline) was evaluated on Changes in pulmonary blood volume (decrease of 2.9 ml/kg (26%), p=<0.001). Continuous intravenous infusion of serotonin lowered pulmonary blood volume by an average of 2.9 ml/kg, or 26% of the control value.
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