Key result
Increases in pulmonary blood flow and pulmonary venous pressure decreased calculated pulmonary vascular resistance in both normal and serotonin-constricted vessels in dogs.
Population
Open-chest, intact dogs in which the pulmonary and systemic circulations were separately perfused
Comparison
Changes in pulmonary blood flow, pulmonary… vs Baseline conditions
Design
Preclinical
Authors
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Calculated PVR varies with flow and pressure independent of tone; leaves open its reliability for assessing pulmonary vasoreactivity in humans.
The study demonstrates that the standard formula for calculating pulmonary vascular resistance assesses resistance to flow rather than true vascular tone, as it is highly dependent on physical factors like flow and venous pressure.
Rudolph et al. (1960) studied this question. Changes in pulmonary blood flow and pulmonary venous pressure, with and without serotonin infusion was evaluated on Calculated pulmonary vascular resistance. Increases in pulmonary blood flow and pulmonary venous pressure decreased calculated pulmonary vascular resistance in both normal and serotonin-constricted vessels in dogs.
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