October 1, 1970Cardiovascular Research
Measurement of pulmonary arterial distensibility in the dog
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Discussion
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Implication
Distensibility and compliance fall markedly with hypoxia or serotonin in dogs; leaves open translation to human pulmonary vascular disease.
Key Points
- Determine pulmonary arterial distensibility and compliance in canines under resting conditions, acute hypoxia, and serotonin administration.
- Measured pulmonary arterial pressure, pulmonary arterial flow, and pulmonary capillary flow in 13 dogs (N=13) breathing ambient air.
- Assessed hemodynamic parameters following ventilation with 10% oxygen in nitrogen and during intravenous infusion of serotonin.
- Calculated pulmonary arterial compliance, distensibility, and the vascular time constant (CR) from recorded pressure-flow relationships.
- Baseline pulmonary arterial distensibility and compliance averaged 3.32%/cm H2O and 1.42 ml/cm H2O, respectively, in air-breathing dogs.
- Both hypoxia and serotonin infusion markedly decreased arterial distensibility and compliance alongside an increase in pulmonary arterial resistance.
- The pulmonary arterial time constant (CR) remained constant across a wide range of vascular resistance values under physiological conditions.
Cite This Study
Reuben et al. (1970) studied this question.