Key result
Occlusive shifting of blood flow in dogs (increasing flow by 25-388%) demonstrated a pressure-flow relationship suggesting the relative maximum capacity of the pulmonary vascular bed is similar in man and dog.
Population
Dogs (closed-chest preparation)
Design
Preclinical
Authors
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Indicates similar pulmonary vascular capacity in dogs and humans; extends comparative physiology but leaves open clinical translation.
This preclinical study demonstrates the pressure-flow relationship in the dog pulmonary vascular bed during acute occlusion, suggesting similarities to human pulmonary vascular capacity.
Michael T. Lategola (1958) studied Acute, subtotal pulmonary vascular occlusion. Occlusive shifting of blood flow within the pulmonary vascular bed was evaluated on Relationship of pulmonary artery pressure to pulmonary blood flow. Occlusive shifting of blood flow in dogs (increasing flow by 25-388%) demonstrated a pressure-flow relationship suggesting the relative maximum capacity of the pulmonary vascular bed is similar in man and dog.
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