Key result
Acute LV infravalvular obstruction reduces coronary blood flow by ~20% in dogs.
Why the study?
The relationship between coronary blood flow and left ventricular peak systolic pressure overload due to infravalvular obstruction was analyzed to understand ischemia in acute left ventricular obstruction.
Acute left ventricular infravalvular obstruction in a canine model leads to a gradient-dependent decrease in coronary blood flow, segment shortening, and stroke volume.
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Experimental model links obstruction to ischemia; leaves open relevance for pediatric clinical practice.
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Katsuro Lagarashi (1983) studied Acute left ventricular obstruction. Infravalvular obstruction via balloon catheter was evaluated on Coronary blood flow. Acute left ventricular infravalvular obstruction up to a 60mmHg gradient in anesthetized dogs decreased coronary blood flow by 20%.
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