August 1, 1982Circulation ResearchOpen Access

Transmural right ventricular blood flow during acute pulmonary artery hypertension in the sedated dog. Evidence for subendocardial ischemia despite residual vasodilator reserve.

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Population

14 awake dogs

Comparison

Progressive pulmonary artery occlusion, with… vs Control conditions (baseline before occlusion)

Design

Preclinical

Authors

Discussion

Subendocardial hypoperfusion may occur in acute RV overload despite coronary reserve; leaves open therapeutic targeting in human RV failure.

Population

14 awake dogs

Intervention

Progressive pulmonary artery occlusion, with adenosine infusion (4 microM/kg per min) in a subset of 5 dogs to test coronary vasodilator reserve

Comparator

Control conditions (baseline before occlusion)

Outcome

Right and left ventricular myocardial blood flow and right ventricular subendocardial-to-subepicardial blood flow ratiosurrogate

Acute severe right ventricular pressure overload causes subendocardial hypoperfusion despite the presence of residual coronary vasodilator reserve.

Gold et al. (1982) studied this question.

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Subendocardial hypoperfusion may occur in acute RV overload despite coronary reserve; leaves open therapeutic targeting in human RV failure.