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May 1, 1981Journal of Clinical InvestigationOpen Access

During exercise, dogs with RV hypertrophy had a smaller increase in right coronary artery blood flow and a smaller decrease in right coronary vascular resistance compared to normal dogs (P<0.05), followed by striking postexercise coronary hyperemia (P<0.01).

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Why the study?

Does severe right ventricular hypertrophy alter the coronary vascular response to strenuous exercise in dogs?

Population

Normal dogs and dogs with severe right ventricular hypertrophy induced by chronic pulmonary artery stenosis.

Comparison

Strenuous, spontaneous exercise. vs Normal dogs undergoing the same exercise.

Design

Preclinical

Authors

PMPaul A. MurraySVStephen F. Vatner

Discussion

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Overview

RV hypertrophy may limit coronary adaptation to exercise in dogs; hypothesis-generating and leaves open human applicability.

Structured PICO

Does severe right ventricular hypertrophy alter the coronary vascular response to strenuous exercise in dogs?

P
Population
Normal dogs and dogs with severe right ventricular (RV) hypertrophy induced by chronic (5-6 months) pulmonary artery stenosis.
I
Intervention
Strenuous, spontaneous exercise.
C
Comparator
Normal dogs undergoing the same exercise.
O
Outcome
Right coronary artery blood flow and right coronary vascular resistance during exercise.surrogate

Severe right ventricular hypertrophy in dogs impairs the ability of the coronary circulation to meet the elevated metabolic demands of exercise, suggesting a perfusion deficit.

Cite This Study

Murray et al. (1981) studied this question.

synapsesocial.com/papers/6a708f86abc331a858079be7https://doi.org/10.1172/jci110160
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of coronary stenosis on myocardial blood flow during exercise in the chronically pressure-overloaded hypertrophied left ventricle.1990 · 12 citations
  2. 2Effects of exerimental right ventricular hypertrophy on myocardial blood flow in conscious dogs.1979 · 77 citations
  3. 3Alterations of myocardial blood flow associated with experimental canine left ventricular hypertrophy secondary to valvular aortic stenosis.1986 · 115 citations
  4. 4Reduced Vasodilator Response of the Right Coronary Artery to Myocardial lschemia in the Hypertrophied Right Ventricle1996 · 2 citations
  5. 5Coronary blood flow in experimental canine left ventricular hypertrophy.1978 · 189 citations