Key result
In dogs with right ventricular hypertrophy, the reactive hyperemic response to brief right coronary artery occlusion was markedly attenuated, with higher minimum coronary resistance (p<0.02).
Why the study?
Does pressure-induced right ventricular hypertrophy attenuate the reactive hyperemic response of the right coronary artery to brief coronary occlusion in dogs?
Population
8 dogs with pressure-induced right ventricular hypertrophy via chronic pulmonary artery banding, and an…
Comparison
Brief right coronary artery occlusion lasting 5… vs Normal dogs subjected to the same brief RCA…
Design
Preclinical
Authors
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RV hypertrophy findings in dogs warrant no practice change; leaves open whether inadequate coronary reserve develops in human pressure overload.
Does pressure-induced right ventricular hypertrophy attenuate the reactive hyperemic response of the right coronary artery to brief coronary occlusion in dogs?
p-value: p=<0.02
Right ventricular hypertrophy attenuates the right coronary artery's vasodilator response to acute ischemia, suggesting inadequate coronary vasculature development.
Saito et al. (1996) studied Right ventricular hypertrophy (n=8). Brief right coronary artery occlusion vs. Normal dogs was evaluated on Reactive hyperemic response (peak reactive flow rate and excess blood flow debt repayment) (p=<0.02). In dogs with right ventricular hypertrophy, the reactive hyperemic response to brief right coronary artery occlusion was markedly attenuated, with higher minimum coronary resistance (p<0.02).
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