Key result
Right ventricular hypertrophy induced by pulmonary artery stenosis in pigs led to significant remodeling of the coronary arterial vasculature, including decreased total right coronary artery resistance.
Why the study?
Does right ventricular hypertrophy induce coronary arterial tree remodeling in a pig model?
Population
9 pigs (6 with right ventricular hypertrophy induced by pulmonary artery stenosis, 3 controls)
Comparison
Right ventricular hypertrophy induced by… vs Control pigs (n=3)
Design
Preclinical
Follow-up
5 weeks
Authors
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RV hypertrophy-linked coronary remodeling in pigs is hypothesis-generating; human studies needed before clinical relevance.
Does right ventricular hypertrophy induce coronary arterial tree remodeling in a pig model?
Right ventricular hypertrophy induces significant remodeling of the coronary arterial vasculature, characterized by the formation of new flow channels and decreased coronary resistance.
Kassab et al. (1993) studied Right ventricular hypertrophy (n=9). Right ventricular hypertrophy induced by pulmonary artery stenosis vs. Control pigs was evaluated on Coronary vascular adaptations (morphometric data of right coronary arteries). Right ventricular hypertrophy induced by pulmonary artery stenosis in pigs led to significant remodeling of the coronary arterial vasculature, including decreased total right coronary artery resistance.
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