March 1, 1993Circulation Research

Coronary pressure-flow relation in left ventricular hypertrophy. Importance of changes in back pressure versus changes in minimum resistance.

View Full Paper

Ask AI

Bookmark

Population

17 dogs

Comparison

Maximum coronary vasodilation produced by… vs Maximum coronary vasodilation produced by…

Design

Preclinical

Authors

DDDirk J. DunckerGeneral Cardiology JZJianyi ZhangGuangzhou University of Chinese Medicine RBR J BacheUniversity of Minnesota Medical Center

Discussion

Member takes

Implication

May underlie LVH perfusion deficits via dual mechanisms; leaves open human translation and therapeutic targeting.

Structured PICO

Population

17 dogs (8 with ascending aortic banding at 6-8 weeks of age to induce left ventricular hypertrophy, and 9 normal dogs)

Intervention

Maximum coronary vasodilation produced by infusion of adenosine (1 mg/kg per minute i.v.) in the setting of left ventricular hypertrophy

Comparator

Maximum coronary vasodilation produced by infusion of adenosine (1 mg/kg per minute i.v.) in normal dogs

Outcome

Coronary pressure-flow relation (slope [alpha PF] and pressure at zero flow [Pf = 0])surrogate

In a canine model of left ventricular hypertrophy, perfusion abnormalities are driven by both a decrease in minimum coronary resistance slope and an increase in effective back pressure.

Cite This Study

Duncker et al. (1993) studied this question.

synapsesocial.com/papers/6a914d0749be6cf6a846641b https://doi.org/10.1161/01.res.72.3.579

View Full Paper

Ask AI

Bookmark

Coronary pressure-flow relation in left ventricular hypertrophy. Importance of changes in back pressure versus changes in minimum resistance.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coronary pressure-flow relation in left ventricular hypertrophy. Importance of changes in back pressure versus changes in minimum resistance.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider